国产一区二区三区久久精品-国产一区二区三区久久-国产一区二区三区精品视频-国产一区二区三区国产精品-国产一区二区三区高清-国产一区二区三区成人久久片

產品詳情
  • 產品名稱:Anti-RAG2抗體

  • 產品型號:重組激活基因2蛋白抗體
  • 產品廠商:KALANG
  • 產品文檔:
你添加了1件商品 查看購物車
簡單介紹:
Anti-RAG2抗體產品質量穩定,實驗效果明顯,貨期快,價格優惠,歡迎垂詢訂購!我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-RAG2抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹:
Rabbit  Anti-RAG2
Cat. Number:
Anti-RAG2抗體KL-6960R
Quantity size:
0.2ml
Concentration:
1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) Anti-RAG2抗體stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as a E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1.
Also known as:
RAG 2; RAG-2; RAG2; RAG2_HUMAN; Anti-RAG2抗體Recombination activating gene 2; V(D)J recombination activating protein 2; V(D)J recombination-activating protein 2.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, .
Immunogen: KLH conjugated syntheticAnti-RAG2抗體 peptide derived from human RAG2.
Predicted Molecular Weight: 58kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. Anti-RAG2抗體
Optimal working dilutions must be determined by the end user.

標題:
內容:
聯系人:
聯系電話:
Email:
公司名稱:
聯系地址:
 
 
注:1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!

滬公網安備 31011702004399號

主站蜘蛛池模板: 欧美精品国产第一区二区 | 欧美日韩中文字幕一区二区高清 | 狠狠操操 | 成人欧美精品久久久久影院 | 国产精品成人va | 在线日本中文字幕 | 亚洲 另类 在线 欧美 制服 | 欧美成人免费全网站大片 | 日本黄色一级网站 | 欧美日韩精选 | 99精品一区二区三区 | 国产福利在线观看一区二区 | 一级欧美一级日韩片 | aaa毛片在线 | 欧美日韩在线一区 | 亚洲第一成网站 | 日本免费二区三区久久 | 国产欧美精品一区二区色综合 | 欧美片免费观看网址 | 欧美在线操 | 免费的三级毛片 | 996久久国产精品线观看导航 | 在线观看一区二区三区四区 | 香蕉伊思人在线精品 | 国产91在线播放动漫 | 欧美高清观看免费全部完 | 亚洲 欧美 成人日韩 | 手机看片国产永久1204 | 亚洲免费不卡 | 三级纯黄 | 在线看片a| 无人视频免费观看免费视频 | 一区二区精品在线观看 | 日本在线观看高清不卡免v 日本在线观看的免费 | 99在线看| 亚洲第一区二区快射影院 | 免费国产va在线观看视频 | 日不卡 | 女人18片免费视频网站 | 青青青久热国产精品视频 | 欧美亚洲日本国产综合网 |