国产一区二区三区久久精品-国产一区二区三区久久-国产一区二区三区精品视频-国产一区二区三区国产精品-国产一区二区三区高清-国产一区二区三区成人久久片

產品詳情
  • 產品名稱:Anti-RAG2抗體

  • 產品型號:重組激活基因2蛋白抗體
  • 產品廠商:KALANG
  • 產品文檔:
你添加了1件商品 查看購物車
簡單介紹:
Anti-RAG2抗體產品質量穩定,實驗效果明顯,貨期快,價格優惠,歡迎垂詢訂購!我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-RAG2抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹:
Rabbit  Anti-RAG2
Cat. Number:
Anti-RAG2抗體KL-6960R
Quantity size:
0.2ml
Concentration:
1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) Anti-RAG2抗體stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulin allele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. In addition to its endonuclease activity, RAG1 also acts as a E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination. Mediates polyubiquitination of KPNA1.
Also known as:
RAG 2; RAG-2; RAG2; RAG2_HUMAN; Anti-RAG2抗體Recombination activating gene 2; V(D)J recombination activating protein 2; V(D)J recombination-activating protein 2.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, .
Immunogen: KLH conjugated syntheticAnti-RAG2抗體 peptide derived from human RAG2.
Predicted Molecular Weight: 58kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. Anti-RAG2抗體
Optimal working dilutions must be determined by the end user.

標題:
內容:
聯系人:
聯系電話:
Email:
公司名稱:
聯系地址:
 
 
注:1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!

滬公網安備 31011702004399號

主站蜘蛛池模板: 日韩日韩 | 夜夜超b天天 | 亚洲欧美一区二区三区国产精品 | 亚洲天堂一区二区三区四区 | 久久免费视频99 | 欧美日韩精品一区二区另类 | 女人张开腿让男人桶免费最新 | 一区高清 | 精品国产精品国产偷麻豆 | 欧美日韩成人午夜免费 | 一区二区三区免费在线观看 | 欧美高清另类video | 日韩欧美一区在线观看 | 蜜柚影视免费版在线视频观看 | 日韩成人av在线 | 狼伊千合综网中文 | 一级做a爱片特黄在线观看免费看 | 久久尹人香蕉国产免费天天 | 欧美极品欧美日韩 | 四虎成人免费网站在线 | 爽爽日本在线视频免费 | 成人免费视频网站 | 欧美亚洲另类在线 | 在线观看日本免费 | 亚洲欧美另类国产 | 日韩精品在线观看视频 | 一级片免费观看视频 | 一及毛片 | 欧美影院一区二区三区 | 理论亚洲区美一区二区三区 | 自拍偷拍第 | 日韩亚洲成a人片在线观看 日韩亚洲 | 网站久久 | 亚洲一区成人 | 国产高清中文字幕 | 久久99精品久久只有精品 | 欧美v日本 | 日本国产一区在线观看 | 在线欧美视频免费观看国产 | 性8成人有声小说在线播放 性88分钟在线播放 性88分钟 | 猛乳3p市来美保天国在线观看 |