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產品詳情
  • 產品名稱:Anti-Simian Rotavirus VP4抗體

  • 產品型號:辛諾柏病毒糖VP4/外層衣殼蛋白VP4/猴輪狀病毒VP4抗體
  • 產品廠商:KALANG
  • 產品文檔:
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簡單介紹:
Anti-Simian Rotavirus VP4抗體產品質量穩定,實驗效果明顯,貨期快,價格優惠,歡迎垂詢訂購!我公司長期供應**組化抗體、WB抗體、**組化試劑盒和抗體試驗所需全部相關試劑、熒光標記抗體、單克隆抗體、多克隆抗體、各種標記的二抗IgG/IgM/IgD/IgA等科研實驗抗體。Anti-Simian Rotavirus VP4抗體用于**組化實驗,WB實驗,相應的標記抗體有HRP標記抗體,FITC標記,BIO等。
詳情介紹:
Rabbit  Anti-Simian Rotavirus VP4
Cat. Number:
Anti-Simian Rotavirus VP4抗體KL-17494R
Quantity size:
0.2ml
Concentration:
1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Simian Rotavirus VP4 (Outer Capsid protein VP4) (Hemagglutinin) functions as a spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to Anti-Simian Rotavirus VP4抗體the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1. VP4 is a homotrimer and adopts a dimeric appearance above the capsid surface, while forming a trimeric base anchored inside the capsid layer. The priming trypsin cleavage triggers its rearrangement into rigid spikes with approximate two-fold symmetry of their protruding parts. After an unknown second triggering event, cleaved VP4 may undergo another rearrangement, in which two VP5* subunits fold back on themselves and join a third subunit to form a tightly associated trimer, shaped like a folded umbrella. VP4 interacts with host ITGA2 (via ITAG2 I-domain); this interaction occurs when ITGA2 is part of the integrin heterodimer ITGA2/ITGB1. VP4 interacts with host integrin heterodimer TGA4/ITGB1 and ITGA4/ITGB7. Proteolytic cleavage by trypsin results in activation of VP4 functions and greatly increases infectivity. The penetration into the host cell is dependent on trypsin treatment of VP4. It produces two peptides, VP5* and VP8* that remain associated with the virion.
Also known as:
Hemagglutinin; VP4_ROTSS; Outer Anti-Simian Rotavirus VP4抗體Capsid protein VP4 (Hemagglutinin); Outer capsid protein VP4; RVA s4gp1; RVAs4gp1; VP4; Outer capsid protein VP4; Outer capsid protein VP5*; Simian Rotavirus VP5*.
Specificity:
Rabbit Polyclonal IgG, affinity purified by Protein A.
Reacts with: Simian Rotavirus.
Immunogen: KLH conjugated synthetic Anti-Simian Rotavirus VP4抗體peptide derived from Simian Rotavirus VP4.
Predicted Molecular Weight: 58/85kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. Anti-Simian Rotavirus VP4抗體
Optimal working dilutions must be determined by the end user.

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